RNase
Noun
Meaning
a transferase that catalyzes the hydrolysis of ribonucleic acid
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Another cellular enzyme, RNAse L —also induced by interferon action—destroys RNA within the cells to further reduce protein synthesis of both viral and host genes.
They concluded that the protein protected the RNA from RNAse, but that once the two were separated and the phage was inactivated, the DNAse could hydrolyze the phage DNA.
Originally, it was believed that, in the bacterial RNase P complex, the protein subunit was responsible for the catalytic activity of the complex, which is involved in the maturation of tRNAs.
In addition to the transcription function, retroviral reverse transcriptases have a domain belonging to the RNase H family, which is vital to their replication.
RNase removes the primer RNA fragments, and a low processivity DNA polymerase distinct from the replicative polymerase enters to fill the gaps.
The catalytic amino acids of the RNase H active site and the polymerase active site are shown in ball-and-stick form.