spliceosome

Noun

Meaning

spliceosome (plural spliceosomes)

English Wikipedia has an article on:spliceosomeWikipedia
(genetics) A dynamic complex of RNA and protein subunits that removes introns from precursor mRNA.

Examples

Another theory is that the spliceosome and the intron-exon structure of genes is a relic of the RNA world (the introns-first hypothesis). citation There is still considerable debate about the extent to which of these hypotheses is most correct. Source: Internet

Group I and II introns perform splicing similar to the spliceosome without requiring any protein. Source: Internet

First, the 2'OH of a specific branchpoint nucleotide within the intron, defined during spliceosome assembly, performs a nucleophilic attack on the first nucleotide of the intron at the 5' splice site, forming the lariat intermediate. Source: Internet

Assembly and activity of the spliceosome occurs during transcription of the pre-mRNA. Source: Internet

In addition, a number of proteins including U2 small nuclear RNA auxiliary factor 1 (U2AF35), U2AF2 (U2AF65) citation and SF1 are required for the assembly of the spliceosome. Source: Internet

This similarity suggests that Group I and II introns may be evolutionarily related to the spliceosome. Source: Internet

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