thymocyte
Noun
Meaning
thymocyte (plural thymocytes)
a lymphocyte, produced in the thymus, that develops into a T cell
Examples
Acquired T cell deficiencies can also affect thymocyte development in the thymus.
Immunodeficiency As the thymus is the organ of T-cell development, any congenital defect in thymic genesis or a defect in thymocyte development can lead to a profound T cell deficiency in primary immunodeficiency disease.
The T-cell receptor undergoes genetic rearrangement during thymocyte maturation, resulting in each T-cell bearing a unique T-cell receptor, specific to a limited set of peptide MHC combinations.
The cortex is the location of the earliest events in thymocyte development, where T cell receptor gene rearrangement and positive selection takes place.