topoisomerase

Noun

Meaning

topoisomerase (plural topoisomerases)

(biochemistry) Any of several enzymes that affect the topology of DNA, especially ones that relax supercoiling.
Synonym: isotopomerase

Anagrams

Examples

For many gram-negative bacteria, DNA gyrase is the target, whereas topoisomerase IV is the target for many gram-positive bacteria. Source: Internet

Drugs that target topoisomerase II can be divided into two groups. Source: Internet

Finally, mutations at key sites in DNA gyrase or topoisomerase IV can decrease their binding affinity to quinolones, decreasing the drugs' effectiveness. Source: Internet

Irinotecan inhibits topoisomerase 1, consequently the cytostatic effect is increased Jia Jia et al: "Mechanisms of drug combinations: interaction and network perspectives." Source: Internet

The most common secondary neoplasm is secondary acute myeloid leukemia, which develops primarily after treatment with alkylating agents or topoisomerase inhibitors. Source: Internet

Then, topoisomerase 1 tries to repair the damage. Source: Internet

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