transferrin
Noun
Meaning
a globulin in blood plasma that carries iron
Source: WordNetSynonyms
Hypernyms
Examples
Cerium may bind in the place of iron on to the transferrin and then be brought into the cancer cells by transferrin-receptor mediated endocytosis.
At the bone marrow, transferrin is reduced from Fe 3+ and Fe 2+ and stored as ferritin to be incorporated into hemoglobin.
Cells treated with just cerium had decreases in cell viability, but cells treated with both cerium and transferrin had more significant inhibition for cellular activity.
Because transferrin also transports iron, excessive iron reduces zinc absorption, and vice versa.
Cancer cells have much higher levels of transferrin receptors than normal cells and are very dependent on iron for their proliferation.
Iron toxicity occurs when the cell contains free iron, which generally occurs when iron levels exceed the availability of transferrin to bind the iron.