ubiquitin

Noun

Meaning

English Wikipedia has an article on:ubiquitinWikipedia
ubiquitin (plural ubiquitins)

(biochemistry) Any of a class of small protein, or polypeptide, present in the cells of all eukaryotes, that play a part in modifying and degrading proteins.

Related terms

Examples

Altering the chain conformations exposes and conceals different parts of the ubiquitin protein, and the different linkages are recognized by proteins that are specific for the unique topologies that are intrinsic to the linkage. Source: Internet

Each end of the core particle associates with a 19S regulatory subunit that contains multiple ATPase active sites and ubiquitin binding sites; it is this structure that recognizes polyubiquitinated proteins and transfers them to the catalytic core. Source: Internet

DUBs cleave these proteins to produce active ubiquitin. Source: Internet

First, a ubiquitin molecule is bonded by its C-terminus to a specific lysine residue on the target protein. Source: Internet

Following addition of a single ubiquitin moiety to a protein substrate, further ubiquitin molecules can be added to the first, yielding a polyubiquitin chain. Source: Internet

HIF is synthesized consititutively, and hydroxylation of at least one of two critical proline residues mediates their interaction with the von Hippel Lindau E3 ubiquitin ligase complex, which targets them for rapid degradation. Source: Internet

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