I started on the downers which were a hell of a lot better than the uppers because I was a nervous wreck. Corey Haim
If you have one pair of good soles it is better than two pairs of good uppers. Irish Proverb
In 1964, the founding of Nike by Phil Knight and Bill Bowerman of the University of Oregon introduced many new improvements common in modern running shoes, such as rubber waffle soles, breathable nylon uppers, and cushioning in the mid-sole and heel. Source: Internet
And plenty of old timers used uppers in the belief that they improved their game. Source: Internet
Protective features may include steel-tipped toes and soles or ankle guards. citation Dress and casual Dress shoes are characterized by smooth and supple leather uppers, leather soles, and narrow sleek figure. Source: Internet
Due to their effects typically having an "up" quality to them, stimulants are also occasionally referred to as "uppers". Source: Internet