varenicline
Noun
Meaning
varenicline (uncountable)
(pharmacology) A drug taken orally in the form of its tartrate C13H13N3·C4H6O6 as an aid to stop smoking. It binds to nicotinic cell receptors to block the activity of nicotine while also acting as an agonist to reduce nicotine cravings and withdrawal symptoms. It is marketed under the trademark Chantix.
Phrases with the word
Examples
Co-administration of an OCT2 inhibitor, cimetidine (300 mg four times daily), with varenicline (2 mg single dose) to 12 smokers increased the systemic exposure of varenicline by 29% (90% CI: 21.5%, 36.9%) due to a reduction in varenicline renal clearance.
By contrast, among men there were no differences in the likelihood of successfully quitting smoking when given varenicline, bupropion or nicotine patch.