acetylation
Noun
Meaning
the process of introducing an acetyl group into a compound
Source: WordNetSynonyms
Hypernyms
Related terms
Examples
the acetylation of cyclooxygenase-2 by aspirin
Aspirin is able to acetylate several other targets in addition to COX isoenzymes. citation citation These acetylation reactions may explain many hitherto unexplained effects of aspirin.
Functionally, however, the acetylation of lysine residues is used to regulate the binding of proteins to nucleic acids.
For example, acetylation of the K14 and K9 lysines of the tail of histone H3 by histone acetyltransferase enzymes (HATs) is generally related to transcriptional competence.
For example, Histone acetylation results in loosening and increased accessibility of chromatin for replication and transcription.
The acetylation event converts the positively charged amine group on the side chain into a neutral amide linkage.