caspase

Noun

Meaning

any of a group of proteases that mediate apoptosis

Hypernyms

Examples

A caspase 8 knock-out leads to cardiac failure and thus embryonic lethality. Source: Internet

A caspase 9 knock-out leads to a severe brain malformation. Source: Internet

Apaf-1 is the protein that turns on caspase 9 by cleavage to begin the caspase cascade that leads to apoptosis. Source: Internet

However, with the use of cre-lox technology, a caspase 8 knock-out has been created that exhibits an increase in peripheral T cells, an impaired T cell response, and a defect in neural tube closure. Source: Internet

Lamin cleavage is sometimes used as a laboratory indicator of caspase activity in assays for early apoptotic activity. Source: Internet

Finally, a caspase 3 knock-out was characterized by ectopic cell masses in the brain and abnormal apoptotic features such as membrane blebbing or nuclear fragmentation. Source: Internet

Close letter words and terms