Cox-1
Noun
Meaning
an enzyme that regulates prostaglandins that are important for the health of the stomach lining and kidneys
Source: WordNetSynonyms
Hypernyms
Examples
an unfortunate side effect of NSAIDs is that they block Cox-1
COX-1 and COX-2 inhibition At least two different types of cyclooxygenase occur COX-1 and COX-2.
COX-1 and COX-2 enzymes may be blocked by pain medications such as Advil and Vioxx in a more complex manner than was previously understood, a Queen's University study has found.
Older NSAIDs include drugs like Naprosyn, which inhibits mostly COX-1; Advil®, which inhibits COX-1 and COX-2; and Voltaren® and Mobic®, which mostly inhibit COX-2.
Ketoprofen is used for its antipyretic, analgesic, and anti-inflammatory properties by inhibiting cyclooxygenase-1 and -2 (COX-1 and COX-2) enzymes reversibly, which decreases production of proinflammatory prostaglandin precursors.
COX-1 is a constitutively expressed enzyme with a "house-keeping" role in regulating many normal physiological processes.