denature
Verb
Meaning
make (alcohol) unfit for drinking without impairing usefulness for other purposes
modify (as a native protein) especially by heat, acid, alkali, or ultraviolet radiation so that all of the original properties are removed or diminished
add nonfissionable material to (fissionable material) so as to make unsuitable for use in an atomic bomb
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Because lysosomal membranes are rich in proton pumps, their interiors have low pH (≈4.8 vs. the pH≈7.2 cytosol), which acts to denature the GPCRs.
Superoxide is known to denature enzymes, oxidize lipids, and fragment DNA.
Temperatures above or below the range that cells tend to live in will cause thermally unstable proteins to unfold or " denature " (this is why boiling makes an egg white turn opaque).
Typical preparation Poaching allows the proteins to denature without pulling out too much (if any at all) moisture out of it.
When insects ingest toxin crystals, their alkaline digestive tracts denature the insoluble crystals, making them soluble and thus amenable to being cut with proteases found in the insect gut, which liberate the toxin from the crystal.