To drive a truck means to operate a large motor vehicle designed for carrying goods. It can refer to steering, shifting, and controlling it, or the job of hauling loads on roads.
There's often a lot of stupid ideas like "you all dress as fruits and pretend you're selling underpants" or "we'll put you on a bed of nails and drive a truck over the top and photograph you" for the cover. Dave Matthews
Your master plan has holes big enough to drive a truck through. Ilona Andrews
My advice is: if you've got to be miserable to write great music, then drive a truck. Chris Isaak