Noun
hydroxylase (plural hydroxylases)
(biochemistry) Any of several enzymes that catalyze the oxidation of compounds by the introduction of hydroxyl groups.
Both PKU and most non-PKU hyperphenylalaninemia are the result of phenylalanine hydroxylase deficiency (PAHD). Source: Internet
In animals including humans, serotonin is synthesized from the amino acid L - tryptophan by a short metabolic pathway consisting of two enzymes : tryptophan hydroxylase (TPH) and aromatic amino acid decarboxylase (DDC). Source: Internet
Severe diseases such as scurvy can result from defects in this hydroxylation, e.g., mutations in the enzyme prolyl hydroxylase or lack of the necessary ascorbate (vitamin C) cofactor. Source: Internet
Phloretic acid is also a urinary metabolite of tyrosine in rats. citation Ortho- and meta-tyrosine Enzymatic oxidation of tyrosine by phenylalanine hydroxylase (top) and non-enyzmatic oxidation by hydroxyl free radicals (middle and bottom). Source: Internet
Glucocorticoids produced in the adrenal cortex stimulate the synthesis of catecholamines by increasing the levels of tyrosine hydroxylase and PNMT. Source: Internet
Phenylketonuria is caused by absent or virtually absent phenylalanine hydroxylase (PAH) enzyme activity. Source: Internet