hydroxylation

Noun

Meaning

hydroxylation (plural hydroxylations)

(organic chemistry) The introduction of a hydroxyl group into a molecule, especially by the replacement of a hydrogen atom

Synonyms

Examples

HIF is synthesized consititutively, and hydroxylation of at least one of two critical proline residues mediates their interaction with the von Hippel Lindau E3 ubiquitin ligase complex, which targets them for rapid degradation. Source: Internet

Severe diseases such as scurvy can result from defects in this hydroxylation, e.g., mutations in the enzyme prolyl hydroxylase or lack of the necessary ascorbate (vitamin C) cofactor. Source: Internet

Amination and hydroxylation has been observed for substituted pyrimidines. Source: Internet

These two enzymes are responsible for the hydroxylation of the proline and lysine amino acids in collagen. Source: Internet

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