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kinetochore

Noun

Meaning

a specialized condensed region of each chromosome that appears during mitosis where the chromatids are held together to form an X shape

Source: WordNet

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the centromere is difficult to sequence Source: Internet

A kinetochore is a proteinaceous microtubule-binding structure that forms on the chromosomal centromere during late prophase. Source: Internet

In budding yeasts, the centromere region is relatively small (about 125 bp DNA) and contains two highly conserved DNA sequences that serve as binding sites for essential kinetochore proteins. Source: Internet

In this chromatin, the normal histone H3 is replaced with a centromere-specific variant, CENP-A in humans. citation The presence of CENP-A is believed to be important for the assembly of the kinetochore on the centromere. Source: Internet

When a microtubule connects with the kinetochore, the motor activates, using energy from ATP to "crawl" up the tube toward the originating centrosome. Source: Internet

In mitosis, the force of kinetochore microtubules pulling in opposite directions creates tension. Source: Internet

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