MAOI
Noun
Meaning
any of a group of antidepressant drugs that inhibit the action of monoamine oxidase in the brain and so allow monoamines to accumulate
Source: WordNetSynonyms
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Indications Newer MAOIs such as selegiline (typically used in the treatment of Parkinson's disease) and the reversible MAOI moclobemide provide a safer alternative and are now sometimes used as first-line therapy.
Interactions Monoamine oxidase inhibitors (MAOI) have been known to prolong and enhance the effects of psilocybin.
Marmite must not be ingested if a person takes a MAOI antidepressant, such as phenelzine (Nardil) or tranylcypromine (Parnate), as yeast extracts interact negatively with these types of medications.
Without RIMAs or the MAOI of MAO-A, DMT would be oxidised (and thus rendered biologically inactive) by monoamine oxidase enzymes in the digestive tract.
In this usage, the DMT is generally considered the main psychoactive active ingredient, while the MAOI merely preserves the psychoactivity of orally ingested DMT, which would otherwise be destroyed in the gut before it could be absorbed in the body.
Taking a MAOI prior to vaporizing or injecting DMT prolongs and potentiates the effects.