methotrexate

Noun

Meaning

toxic antimetabolite that limits cellular reproduction by acting as an antagonist to folic acid; used to treat certain cancers and psoriasis and rheumatoid arthritis

Synonyms

Hypernyms

Phrases with the word

Examples

Although methotrexate is used to treat both multiple sclerosis and ankylosing spondylitis, its efficacy in these diseases is still uncertain. Source: Internet

A treated persistent PUL is defined as one managed medically (generally with methotrexate) without confirmation of the location of the pregnancy such as by ultrasound, laparoscopy or uterine evacuation. Source: Internet

Folic acid supplements have little established role in cancer chemotherapy. citation citation There have been cases of severe adverse effects of accidental substitution of folic acid for folinic acid in patients receiving methotrexate cancer chemotherapy. Source: Internet

For this reason hCG levels may have to be monitored after removal of an ectopic pregnancy to assure their decline, also methotrexate can be given at the time of surgery prophylactically. Source: Internet

However, methotrexate can be toxic, citation citation citation producing side effects, such as inflammation in the digestive tract that make it difficult to eat normally. Source: Internet

Hydroxychloroquine (Plaquenil) is another option and is generally considered safer than methotrexate. Source: Internet

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