Noun
phosphodiesterase (plural phosphodiesterases)
(biochemistry) Any of a family of enzymes that catalyze the cleavage of phosphodiester links in nucleic acids.
It inhibits PDE4 to the greatest extent, but also shows significant inhibition of other PDE subtypes, and so acts as a selective PDE4 inhibitor or a non-selective phosphodiesterase inhibitor, depending on the dose. Source: Internet
The two signal pathways are connected together by Ca 2+ -CaM, which is also a regulatory subunit of adenylyl cyclase and phosphodiesterase in the cAMP signal pathway. Source: Internet
The mechanism of action associated with the drug is that it inhibits cGMP specific phosphodiesterase type 5 (PDE5) and triggers cGMP mediated triggers smooth muscle relaxation and increase in the blood flow in the corpus cavernosum region of the penis. Source: Internet
Yeast tRNA cyclic phosphodiesterase cleaves the cyclic phosphodiester group to form a 2'-phosphorylated 3' end. Source: Internet
ITI-214 in Heart Failure: Clinical conduct in our Phase 1/2 clinical trial of ITI-214, our phosphodiesterase 1 (PDE1) inhibitor, in patients with chronic systolic heart failure has been completed. Source: Internet
Phosphodiesterase 5 (PDE5) inhibitors are a class of oral medications commonly prescribed this day for erection failure. Source: Internet