synthetase
Noun
Meaning
Any enzyme that catalyzes the synthesis of a biological compound.
Synonym: synthase
(dated) Such an enzyme that, more specifically, uses ATP as a source of energy.
Coordinate term: synthase
Synonyms
Phrases with the word
Examples
Formation of amino acids Glutamine is synthesized from glutamate by glutamine synthetase, which utilizes an ATP to form glutamyl phosphate; this intermediate is attacked by ammonia as a nucleophile giving glutamine and inorganic phosphate.
This path begins with a nonribosomal peptide synthetase (NRPS), ACV synthetase (ACVS), which generates the linear tripeptide δ-( L -α-aminoadipyl)- L -cysteine- D -valine (ACV).
Each of the 20 amino acids are recognized by its specific aminoacyl-tRNA synthetase.
Other common names for ligases include the word "synthetase", because they are used to synthesize new molecules.
The condensation reaction and epimerization are both catalyzed by the enzyme δ-( L -α-aminoadipyl)- L -cysteine- D -valine synthetase (ACVS), a nonribosomal peptide synthetase or NRPS.
The enzyme aminoacyl tRNA synthetase "charges" the tRNA molecules with the correct amino acids.