Noun
valproate (plural valproates)
(chemistry, pharmacology) Any salt or ester of valproic acid.
Combination therapy (atypical antipsychotic with lithium or valproate) shows better efficacy over monotherapy in the manic phase in terms of efficacy and prevention of relapse. Source: Internet
Because this medication can be potentially harmful to the fetus, valproate should be considered for women of childbearing potential only after the risks have been discussed. Source: Internet
Dosage of lorazepam should be halved when taken with valproate or probenecid. Source: Internet
Neural tube defects are the congenital malformation most strongly associated with maternal valproate use. Source: Internet
These data show up to a five-fold increased risk for any major malformation following valproate exposure compared to the risk following exposure to other antiepileptic drugs taken in monotherapy. Source: Internet
Concurrent administration of lorazepam with valproate results in increased plasma concentrations and reduced clearance of lorazepam. Source: Internet